Nexavar (Sorafenib) for Desmoid Tumor

Overview
Nexavar, which is approved by the U.S. Food and Drug Administration (FDA) for the treatment of some types of carcinomas, is also sometimes prescribed off-label to treat desmoid tumors. Nexavar is also known by its drug name, sorafenib​​​​​​.

Nexavar belongs to a category of medications known as tyrosine kinase inhibitors, which work by blocking the action of enzymes called tyrosine kinases. These enzymes are involved in the processes that signal cancer cells to grow and divide and in the formation of blood vessels that supply tumors with oxygen and nutrients. By inhibiting these enzymes, Nexavar can help slow the growth of desmoid tumors​​​​​​.

How do I take it?
Nexavar is a tablet taken by mouth. The medication should be taken exactly as prescribed by a health care provider​​.

Side effects
Common side effects of Nexavar include bleeding, feeling tired, vomiting, diarrhea, nausea, stomach pain, high blood pressure, rash, weight loss, and thinning hair. 

Rare but serious side effects may include severe or persistent high blood pressure, heart problems, bleeding problems, liver injury, fetal harm in pregnant people, and dermatologic toxicities. If you experience any severe side effects, contact a health care provider immediately​​​​.

For more information about this treatment, visit:

Label: Nexavar — Sorafenib Tablet, Film Coated — DailyMed

About Desmoid Tumor: Treatment & Monitoring — Desmoid Tumor Research Foundation